"Multicompartment Body Model"
<1. Draw a natural log plasma
concentration versus time profile for a drug administered by the
intravenous bolus route and best characterized by a two
1-a The slope of the terminal
phase of the above plot equals ________________.
1-b The intercept of the
terminal portion on the ln plasma concentration axis is termed
1-c Beta (b) is the
terminal __________constant of the drug
as it leaves the body.
1-d One way to calculate a
distribution rate is to use the method of
1-e the first step in the
method of residuals is to ________
the terminal straight-line portion of the curve.
1-f The extrapolated points
are subtracted from the actual _______________ observed at the corresponding times.
1-g The slope of the residual
line equals ___________________.
1-h "A" is the
__________ of the ln plasma concentration
axis by the __________________ line.
1-i The concept of residuals
attempts to separate the two processes of
2. A 250 mg I.V. dose of amoxicillin was administered to a
healthy, 70-kg 28-year-old male. The disposition following
administration was described by the equation:
Explain in your own words why
the values for Vdc and Vdss differ (no equations).
3. Explain, why there are
differences in Vc and Vdss in a two compartment body model.
4. Pharmacokinetic models are
used to describe plasma-concentration time profiles after defined
forms of administration. Select from the following list (a-g) the
correct model for each of the profiles (1-5) shown below.
a. 2 compartment body model,
b. 1 compartment body model,
c. repetitive injection with
d. repetitive injection
without loading dose
e. oral absorption (1 tablet)
plus i.v. injection
f. pulmonary inhalation (1
puff from a metered dose inhaler)
g. none of the above
5. Mark whether the following
statements are true or false.